Medical Minute; Can cannabis help repair arthritic Joints?

Can Cannabis Help Repair Arthritic Joints?

As our nation’s baby boomers age, they’re facing a multitude of health-related ailments and costs. One of the most prominent concerns is the prevalence of chronic arthritis, an ailment that affects 52.5 million adults today, and that number is expected to increase to 67 million by 2030. There’s no cure for arthritis, and limited treatment options exist for the painful and limiting disease.

One alternative that’s gaining popularity among the aging population is the use of cannabis to get full-bodied pain relief and anti-inflammatory properties. Although arthritis is considered a qualifying condition in at least two states, there’s a remarkable lack of data and research behind the effectiveness of cannabis as a treatment alternative for arthritis, osteoarthritis, and rheumatoid arthritis.

Arthritis is an uncomfortable and often unavoidable disease that often results in severe symptoms:

  • Injuries that don’t heal properly
  • Carpal tunnel syndrome and peripheral neuropathies (tingling or numbness in extremities)
  • Plantar fasciitis (inflammation of the forefoot)
  • Persistent joint pain
  • Locked joints
  • Morning stiffness

A study published in the journal Rheumatology from Dr. Sheng-Ming Dai of China’s Second Military Medical University found that CB2 receptors are found in unusually high levels in the joint tissue of arthritis patients. The use of cannabis is shown to fight inflammation in the joints by activating the pathways of CB2 receptors.

Canadian researcher Dr. Jason McDougall, a professor of pharmacology and anesthesia at Dalhousie University in Halifax, has undertaken a new study to find out if medical marijuana can help repair arthritic joints and relieve pain. The study is supported by the Arthritis Society and is awarding a grant for a comprehensive, three-year study to investigate if cannabis is not just dampening the pain in the brain, but also working to fight inflammation and repair the joint itself.

When asked to describe the nerves of an arthritis sufferer, McDougall told CBC Radio’s Information Morning the following information:

“[The nerves are like] wires that have been stripped of their coating. They’re all bare, they’re all raw and responsible for feeling a lot of pain. What we hypothesize is that by locally administering these cannabis-like molecules to those nerves, we’d actually be able to repair them and reduce the pain of arthritis.”

McDougall’s research is focused on non-psychoactive cannabinoids, but so far, his findings has shown that cannabis molecules can attach themselves to nerve receptors and control the firing of pain signals in the joint. Indeed, it’s been proven in certain anecdotal circumstances, such as the case of Katie Marsh of Madawaska, Maine. A sufferer of rheumatoid arthritis, she was on a prescription of prednisone and antibiotics and was encouraged by her doctors to try disease-modifying anti-rheumatic drugs (DMARDS), but the side effects were severe enough that she sought a natural way to ease her pain and swollen joints.

After seeking the advice of a physician that specializes in dietary cannabis, Marsh began juicing raw cannabis, blending it into a smoothie and consuming the whole raw plant. She began to see results almost immediately — within days, Marsh was off the prednisone and even pain killers. After 11 months of regular cannabis juicing, her condition is in remission.

Now that Health Canada has approved the study, titled the CAPRI trial (Cannabinoid Profile Investigation of Vaporized Cannabis in Patients with Osteoarthritis of the Knee), researchers in Halifax and Montreal are seeking volunteers over the age of 50 who suffer from osteoarthritis of the knee to participate in the year study, which will be a randomized, double-blind, placebo-controlled study that involves visits to the physician and exposure to six different types of cannabis through a vaporizer, all with varying levels of THC and CBD.

Two Canadian licensed producers of medical marijuana, Aphria, Inc. and the Peace Naturals Project, contributed $100,000 each to the Arthritis Society to fund the grant, and the research project has been approved by Health Canada. Researchers hope to start the study by September, and preliminary results will be collected by the end of 2016.

If you’re interested in cannabis for arthritis, check out our list of cannabis strains that may help treat arthritis symptoms.

 

Article from:

Leafly (2017). By Lisa Rough

Cannabis and Sleep: 10 Things to Know About Your Herbal Nightcap

Cannabis can be a splendid sleep aid, which is why many consumers keep a go-to favorite by their bedside. Even people with the most stubborn insomnia can find their escape to the dream world with a nice sedating indica. While most consumers are aware that cannabis can help you get a good night’s sleep, there’s a lot more to that relationship than you might think. For example, did you know older dried cannabis makes you sleepier than fresh bud? And did you know that marijuana inhibits dreams?

Get ready to learn a thing or two about the ways cannabis can help or hinder your nightly hibernation.

1. CBD and THC Affect Sleep Differently

By now you probably know that there are different types of strains: some get you high (high-THC, low-CBD), some don’t (high-CBD, low-THC), and others keep your buzz at a minimum (equal or near-equal parts THC and CBD). It’s worth first noting that most sleep studies – as well as the facts to follow –pertain to high-THC strains, as CBD strains are significantly harder (if not impossible) to find in some areas of the U.S.

So what effect do high-CBD strains have on sleep? A 2006 study tested the effects of CBD on animal models in both lights-on and lights-off environments and found that this non-psychoactive cannabis compound increased alertness with the lights on and had no discernable effects on lights-off sleep. The study’s authors concluded that CBD might actually hold therapeutic promise for those with somnolence, or excessive daytime sleepiness from a not-so-good night’s rest.

 

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2. Indica Strains Tend to Be Better Sleep Aids

Popular opinion maintains that indica strains tend to induce heavier, sleepy effects while sativas are known to be uplifting, even energizing. Take a look at our top-rated sleepy strainsand you’ll see a wall of indica purple patched with a little hybrid green. Although chemical and DNA testing have yet to show exactly why indicas typically make better sleep aids, some theorize that it has to do with the terpene content – that is, the aromatic compounds that contribute to each strain’s special effect fingerprint. In other words, indicas may contain more of the relaxing, sedating terpenes than its sativa relatives.

 

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3. Aged Cannabis Makes You Sleepier

No, really. When THC degrades over time, it converts to a sedating chemical known as cannabinol, or CBN. This cannabis compound is five times more sedating than THC, though it’s fairly slow to form. Chief Research Officer Rev. Dr. Kymron deCesare of Steep Hill Labs elaborates on this process.

“As d9-THC degrades through both isomerization and/or oxidatively, only a small portion of it turns into CBN. As a result, CBN is a bit difficult to collect in large quantities for usage. My experience is that if I take cannabis that is about 20% THCA, and I wrap in in plastic and let it sit in the garage for 3 years (in summer heat and dry), it results in a 3-5% production of CBN. Yes, I use ‘old weed’ to make sedative medicinals.”

 

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4. Natural Remedies Help Maximize Cannabis’ Sleepy Effects

Cannabis is a great way to ready yourself for sleep, but pairing it with other natural sleep aids can make for an even more restful night. “Other terpenoids are extremely synergistic with CBN, some in the cannabis plant, some I add from other herbals,” Rev. Dr. deCesare told us. “Hops, chamomile, and lavender contain important terpenes also found in cannabis, but found in much higher concentration. These inclusions in the medical remedy will make for a greatly enhance sedation efficacy.”

So next time you bust out your favorite sleepy strain, think about pairing it with a cup of chamomile tea or a lavender bubble bath. Melatonin, 5-HTP, and valerian root supplements may also help improve your sleep quality.

 

 

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5. Cannabis Can Help You Fall Asleep Faster

Given its ability to quell stress and relax physically, it should come as no surprise that cannabis can help you fall asleep faster. This can be especially true for those treating paininsomniaPTSDmultiple sclerosis, or other conditions that interfere with the ability to fall asleep as cannabis relieves many bothersome symptoms. It’s worth noting that cannabis-infused edibles take longer to kick in than inhalation methods, but their effects can last several hours and help you stay asleep longer.

 

 

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6. Nighttime Cannabis Use May Cause a “Hangover”

Ever notice that your head might feel a little groggy in the morning after your nightcap? Cannabis can cause mild “hangovers” – no, you won’t be hunched over a toilet while daggers stab at your head, but you might feel a little foggy, dehydrated, lethargic, dry-eyed, or congested. This phenomenon may have never happened to you (high-five). Others have experienced bad hangovers from smoking low-grade or pesticide-riddled cannabis. The best way to avoid a bad morning is to buy clean/tested cannabis, drink lots of water, eat healthy foods, and refrain from overindulging. Nurse a hangover much like you would an alcohol hangover – water, exercise, vitamins, etc.

 

 

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7. Cannabis Inhibits REM Sleep and Dreaming

One thing you may find yourself missing while regularly consuming cannabis is dreams. Dreams occur during the final stage of your sleep cycle called REM (rapid eye movement) sleep. Cannabis use before bedtime is shown to reduce the time spent in REM, which means you won’t have as many dreams or as vivid dreams. However, if you halt long-term cannabis use, you’re likely to experience “REM rebound” in which you tend to have more dreams that are more lucid in nature.

 

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8. Cannabis May Promote Better Breathing

Sleep apnea is a sleep condition characterized by frequent obstructions of breath, with lapses that can last anywhere from a few seconds to several minutes. As you can imagine, sleep apnea causes the individual to wake up many times over the course of the night, and leads to a myriad of unpleasant ripple effects like daytime sleepiness, fatigue, headaches, mood disturbances, inattention, increased susceptibility to accident, and other health problems.

Preclinical studies show that cannabis may improve this condition. A 2013 study measured the efficacy of an exogenous cannabinoid known as dronabinol (a THC “mimic”) and noted improvements in 15 out of 17 study participants following 21 days of treatment. Another 2002 study observed THC’s ability to restore respiratory stability by modulating serotonin signaling. We’ll need more confidence from clinical studies to be certain of cannabis’ efficacy, but researchers appear to be off to a good start.

 

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9. Discontinuing Long-Term Use May Worsen Sleep

If you’ve ever quit or taken a tolerance break after long-term cannabis use, you’re probably familiar with this phenomenon. You might find yourself tossing and turning, waking up frequently, or feeling groggy the next day. A 2008 sleep study found that discontinuing long-term use led to shorter sleep time, less slow wave sleep, worse sleep efficiency, longer sleep onset, shorter REM cycles, and more sleep disruption in abstaining subjects than the drug-free control group. However, researchers acknowledge these findings are limited by a small sample size and the inability to determine causation. In other words, it’s possible the study subjects had used cannabis to treat pre-existing insomnia and ceasing use caused a resurgence of sleepless symptoms.

 

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10. Using Cannabis at a Young Age May Cause Sleep Problems

Using cannabis – particularly before the age of 15 – may cause sleeping problems throughout adulthood, according to a 2014 study that took survey information from 1,811 participants with a history of use. The key word there is “may” ­– the study was unable to determine whether cannabis caused worsened sleep or if insomniacs are more likely to use cannabis for its sedative effects. More studies are needed to confirm a causal relationship.

 

 

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Sources:

Leafly.com Article By. BAILEY RAHN